Article
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
eLife - 19 Jul 2021
Stokes Barbara H, Dhingra Satish K, Rubiano Kelly, Mok Sachel, Straimer Judith, Gnädig Nina F, Deni Ioanna, Schindler Kyra A, Bath Jade R, Ward Kurt E, Striepen Josefine, Yeo Tomas, Ross Leila S, Legrand Eric, Ariey Frédéric, Cunningham Clark H, Souleymane Issa M, Gansané Adama, Nzoumbou-Boko Romaric, Ndayikunda Claudette, Kabanywanyi Abdunoor M, Uwimana Aline, Smith Samuel J, Kolley Olimatou, Ndounga Mathieu, Warsame Marian, Leang Rithea, Nosten François, Anderson Timothy Jc, Rosenthal Philip J, Ménard Didier, Fidock David A
Abstract excerpt
The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13-propeller genotyping confirms the emergence of the R561H mutation in Rwanda and highlights the continuing dominance of wild-type K13 elsewhere. Using gene editing, we show that R561H, along with C580Y and M579I, confer elevated...
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