Article
Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates.
Science (New York, N.Y.) - 23 Jan 2015
Straimer Judith, Gnädig Nina F, Witkowski Benoit, Amaratunga Chanaki, Duru Valentine, Ramadani Arba Pramundita, Dacheux Mélanie, Khim Nimol, Zhang Lei, Lam Stephen, Gregory Philip D, Urnov Fyodor D, Mercereau-Puijalon Odile, Benoit-Vical Françoise, Fairhurst Rick M, Ménard Didier, Fidock David A
Abstract excerpt
The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the global malaria burden. We genetically modified the Plasmodium falciparum K13 locus using zinc-finger nucleases and measured ring-stage survival rates after drug exposure in vitro; these rates correlate with parasite clearance half-lives in artemisinin-treated patients. With isolates from Cambodia, where resistance first...
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