A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.

doi:10.1038/nature12876

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Article

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.

Nature - 2 Jan 2014

Ariey Frédéric, Witkowski Benoit, Amaratunga Chanaki, Beghain Johann, Langlois Anne-Claire, Khim Nimol, Kim Saorin, Duru Valentine, Bouchier Christiane, Ma Laurence, Lim Pharath, Leang Rithea, Duong Socheat, Sreng Sokunthea, Suon Seila, Chuor Char Meng, Bout Denis Mey, Ménard Sandie, Rogers William O, Genton Blaise, Fandeur Thierry, Miotto Olivo, Ringwald Pascal, Le Bras Jacques, Berry Antoine, Barale Jean-Christophe, Fairhurst Rick M, Benoit-Vical Françoise, Mercereau-Puijalon Odile, Ménard Didier

Abstract excerpt

Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular marker is urgently needed. Here, using whole-genome sequencing of an artemisinin-resistant parasite line from Africa and clinical parasite isolates from Cambodia, we associate mutations in the PF3D7_1343700 kelch...

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Identifiers

PMID: 24352242
DOI: 10.1038/nature12876
PMCID: PMC5007947

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