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Article

Polymorphisms in the K13-propeller gene in artemisinin-susceptible Plasmodium falciparum parasites from Bougoula-Hameau and Bandiagara, Mali.

The American journal of tropical medicine and hygiene - 1 Jun 2015

Ouattara Amed, Kone Aminatou, Adams Matthew, Fofana Bakary, Maiga Amelia Walling, Hampton Shay, Coulibaly Drissa, Thera Mahamadou A, Diallo Nouhoum, Dara Antoine, Sagara Issaka, Gil Jose Pedro, Bjorkman Anders, Takala-Harrison Shannon, Doumbo Ogobara K, Plowe Christopher V, Djimde Abdoulaye A

Abstract excerpt

Artemisinin-resistant Plasmodium falciparum malaria has been documented in southeast Asia and may already be spreading in that region. Molecular markers are important tools for monitoring the spread of antimalarial drug resistance. Recently, single-nucleotide polymorphisms (SNPs) in the PF3D7_1343700 kelch propeller (K13-propeller) domain were shown to be associated with artemisinin resistance in vivo and in...

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PMID: 25918205
DOI: 10.4269/ajtmh.14-0605
PMCID: PMC4458826

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