Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.

Nature medicine - 1 Oct 2020

Uwimana Aline, Legrand Eric, Stokes Barbara H, Ndikumana Jean-Louis Mangala, Warsame Marian, Umulisa Noella, Ngamije Daniel, Munyaneza Tharcisse, Mazarati Jean-Baptiste, Munguti Kaendi, Campagne Pascal, Criscuolo Alexis, Ariey Frédéric, Murindahabi Monique, Ringwald Pascal, Fidock David A, Mbituyumuremyi Aimable, Menard Didier

Abstract excerpt

Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa1-4. Here we genotyped the P. falciparum K13 (Pfkelch13) propeller domain, mutations in which can mediate artemisinin resistance5,6, in pretreatment samples collected from recent dihydroarteminisin-piperaquine and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimalarials
Share to Artemisinins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clonal Evolution

Share to Communicable Diseases, Emerging

Share to Histidine

Share to Malaria, Falciparum

Share to Parasitic Sensitivity Tests

Share to Rwanda

Source

Open in PubMed Open full text

Identifiers

PMID: 32747827
DOI: 10.1038/s41591-020-1005-2
PMCID: PMC7541349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.PMID 32747827Read ↗

A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa.Semantic proximity Read ↗

Indigenous emergence and spread of kelch13 C469Y artemisinin-resistant Plasmodium falciparum in Uganda.Semantic proximity Read ↗

Plasmodium falciparum kelch 13 Mutations, 9 Countries in Africa, 2014-2018.Semantic proximity Read ↗

Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda.Semantic proximity Read ↗

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.Semantic proximity Read ↗

Association of Plasmodium falciparum kelch13 R561H genotypes with delayed parasite clearance in Rwanda: an open-label, single-arm, multicentre, therapeutic efficacy study.Semantic proximity Read ↗

Molecular assessment of kelch13 non-synonymous mutations in Plasmodium falciparum isolates from Central African Republic (2017-2019).Semantic proximity Read ↗

Clinical evidence of Kelch13-dependent and -independent malaria treatment failure with Artemether-LumefantrineSemantic proximity Read ↗

Plasmodium falciparum non-synonymous Kelch13 mutations mediating artemisinin resistance in East Africa: A systematic review and meta-analysis: 2014-2024.Semantic proximity Read ↗

Genetic Architecture and Dynamics of PfKelch13’s Propeller Domain in Plasmodium Falciparum Clinical Isolates Collected in Senegal.Semantic proximity Read ↗

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.Semantic proximity Read ↗

Spatial and molecular mapping of Pfkelch13 gene polymorphism in Africa in the era of emerging Plasmodium falciparum resistance to artemisinin: a systematic review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.