Article
Functional assessment of prevalent kelch13 mutations reveals high-level artemisinin resistance potential in Bangladeshi Plasmodium falciparum.
mBio - 8 Apr 2026
Nima Maisha Khair, Bhattacharyya Nirjhar, Shoue Douglas, Park Jungyoon, Phru Ching Swe, Sazed Saiful Arefeen, Padmanabhan Prasad K, Kumar Sudhir, Alam Mohammad Shafiul, Ferdig Michael, Mukherjee Angana
Abstract excerpt
Artemisinin partial resistance (ART-R), driven by mutations in the Plasmodium falciparum kelch13 (k13) gene, has contributed to malaria treatment failures in the Greater Mekong Subregion (GMS). The Chittagong Hill Tracts (CHTs) of Bangladesh account for nearly 90% of national malaria cases. Although K13-mediated ART-R has not been reported in the CHTs, its emergence remains a concern due to the region's proximity...
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