Article
Kelch 13-propeller polymorphisms in Plasmodium falciparum from Jazan region, southwest Saudi Arabia.
Malaria journal - 10 Nov 2020
Dafalla Ommer Mohammed, Alzahrani Mohammed, Sahli Ahmed, Al Helal Mohammed Abdulla, Alhazmi Mohammad Mohammad, Noureldin Elsiddig Mohammed, Mohamed Waheed Sideeg, Hamid Tajeldin Bashir, Abdelhaleem Aymen Awad, Hobani Yahya Ali, Arif Ommar Ali, Bokar Ibrahim Munagi, Hakami Abdulazai Mohammed, Eisa Zaki Manawar
Abstract excerpt
BACKGROUND: Artemisinin-based combination therapy (ACT) is recommended at the initial phase for treatment of Plasmodium falciparum, to reduce morbidity and mortality in all countries where malaria is endemic. Polymorphism in portions of P. falciparum gene encoding kelch (K13)-propeller domains is associated with delayed parasite clearance after ACT. Of about 124 different non-synonymous mutations, 46 have been...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.