K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa.

doi:10.1093/infdis/jiu608

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Article

K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa.

The Journal of infectious diseases - 15 Apr 2015

Kamau Edwin, Campino Susana, Amenga-Etego Lucas, Drury Eleanor, Ishengoma Deus, Johnson Kimberly, Mumba Dieudonne, Kekre Mihir, Yavo William, Mead Daniel, Bouyou-Akotet Marielle, Apinjoh Tobias, Golassa Lemu, Randrianarivelojosia Milijaona, Andagalu Ben, Maiga-Ascofare Oumou, Amambua-Ngwa Alfred, Tindana Paulina, Ghansah Anita, MacInnis Bronwyn, Kwiatkowski Dominic, Djimde Abdoulaye A

Abstract excerpt

Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were...

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PMID: 25367300
DOI: 10.1093/infdis/jiu608
PMCID: PMC4827505

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