Article
Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses.
Nature communications - 14 Jul 2021
Alvarado Gabriela, Salmen Wilhelm, Ettayebi Khalil, Hu Liya, Sankaran Banumathi, Estes Mary K, Venkataram Prasad B V, Crowe James E
Abstract excerpt
The rational development of norovirus vaccine candidates requires a deep understanding of the antigenic diversity and mechanisms of neutralization of the virus. Here, we isolate and characterize a panel of broadly cross-reactive naturally occurring human monoclonal IgMs, IgAs and IgGs reactive with human norovirus (HuNoV) genogroup I or II (GI or GII). We note three binding patterns and identify monoclonal...
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