Article
Mapping broadly reactive norovirus genogroup I and II monoclonal antibodies.
Clinical and vaccine immunology : CVI - 1 Feb 2015
Crawford Sue E, Ajami Nadim, Parker Tracy Dewese, Kitamoto Noritoshi, Natori Katsuro, Takeda Naokazu, Tanaka Tomoyuki, Kou Baijun, Atmar Robert L, Estes Mary K
Abstract excerpt
Noroviruses are responsible for most acute nonbacterial epidemic outbreaks of gastroenteritis worldwide. To develop cross-reactive monoclonal antibodies (MAbs) for rapid identification of genogroup I and II (GI and GII) noroviruses (NoVs) in field specimens, mice were immunized with baculovirus-expressed recombinant virus-like particles (VLPs) corresponding to NoVs. Nine MAbs against the capsid protein were...
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