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Article

Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses

2 Jul 2024

Abstract excerpt

Human norovirus was discovered more than five decades ago and is a widespread cause of outbreaks of acute gastroenteritis. There are no approved vaccines or antivirals currently available. However, norovirus inhibitors, including capsid-specific monoclonal antibodies (Mabs) and nanobodies, have recently shown promising results. Several Mabs and nanobodies were found to inhibit norovirus replication using a human...

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PMID: 38953655
DOI: 10.1128/jvi.00707-24

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