Article

Human Norovirus Neutralized by a Monoclonal Antibody Targeting the HBGA Pocket

2018-12-07

Abstract excerpt

Temporal changes in the GII.4 human norovirus capsid sequences occasionally result in the emergence of genetic variants capable of causing new epidemics. The GII.4 persistence is believed to be associated with the recognition of numerous histo-blood group antigen (HBGA) types and antigenic drift. We found that one of the earliest known GII.4 isolate (1974) and a more recent epidemic GII.4 variant (2012) had varied...

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Literature Corpus work: 47fce787-f801-5b15-9cbb-86b4e69ca7f9
DOI: 10.1101/489906

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