Article
Experimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity.
Clinical and vaccine immunology : CVI - 1 Feb 2015
Czakó Rita, Atmar Robert L, Opekun Antone R, Gilger Mark A, Graham David Y, Estes Mary K
Abstract excerpt
The human noroviruses (NoVs) are genetically diverse, rapidly evolving RNA viruses and are the major cause of epidemic gastroenteritis of humans. Serum antibodies that block the interaction of NoVs and NoV viruslike particles (VLPs) with host attachment factors are considered surrogate neutralizing antibodies in the absence of cell culture and small-animal replication models for the human NoVs. A serological...
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