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Article

Characterization of cross-reactive, non-neutralizing monoclonal antibodies against a pandemic GII.4 norovirus variant.

Microbiology spectrum - 5 Dec 2024

Ford-Siltz Lauren A, Tohma Kentaro, Kihn Kyle, Kendra Joseph A, Deredge Daniel, Wintrode Patrick, Gao Yamei, Parra Gabriel I

Abstract excerpt

Antibodies are thought to play a major role in protection against human norovirus infection. Mouse humoral responses closely mimic those of humans; thus, mouse models are used to characterize norovirus epitopes on the major viral capsid protein, VP1. We have developed a panel of mouse monoclonal antibodies (mAbs) produced against the last pandemic variant to emerge, Sydney 2012. While most mAbs (25/44) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39470287
DOI: 10.1128/spectrum.01143-24
PMCID: PMC11619288

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