Article
Broadly neutralizing antibodies targeting pandemic GII.4 variants or seven GII genotypes of human norovirus.
Science translational medicine - 5 Mar 2025
Park Juyeon, Lindesmith Lisa C, Olia Adam S, Costantini Veronica P, Brewer-Jensen Paul D, Mallory Michael L, Kelley Cynthia E, Satterwhite Ed, Longo Victoria, Tsybovsky Yaroslav, Stephens Tyler, Marchioni Jeffrey, Martins Christina A, Huang Yimin, Chaudhary Ridhi, Zweigart Mark, May Samantha R, Reyes Yaoska, Flitter Becca, Vinjé Jan, Tucker Sean N, Ippolito Gregory C, Lavinder Jason J, Snijder Joost, Kwong Peter D, Georgiou George, Baric Ralph S
Abstract excerpt
Human norovirus causes more than 700 million illnesses annually. Extensive genetic diversity and a paucity of information on conserved neutralizing epitopes pose major obstacles to the design of broadly protective norovirus immunogens. Here, we used high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS)-driven proteomics to quantitatively characterize the circulating serum IgG repertoire before...
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