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Article

Immunogenetic Mechanisms Driving Norovirus GII.4 Antigenic Variation

17 May 2012

Abstract excerpt

Noroviruses are the principal cause of epidemic gastroenteritis worldwide with GII.4 strains accounting for 80% of infections. The major capsid protein of GII.4 strains is evolving rapidly, resulting in new epidemic strains with altered antigenic potentials. To test if antigenic drift may contribute to GII.4 persistence, human memory B cells were immortalized and the resulting human monoclonal antibodies (mAbs)...

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PMID: 22615565
DOI: 10.1371/journal.ppat.1002705

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