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Article

Fibrous Caps in Atherosclerosis Form by Notch-Dependent Mechanisms Common to Arterial Media Development.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2021

Martos-Rodríguez Carlos J, Albarrán-Juárez Julián, Morales-Cano Daniel, Caballero Ainoa, MacGrogan Donal, de la Pompa José Luis, Carramolino Laura, Bentzon Jacob F

Abstract excerpt

Objective: Atheromatous fibrous caps are produced by smooth muscle cells (SMCs) that are recruited to the subendothelial space. We tested whether the recruitment mechanisms are the same as in embryonic artery development, which relies prominently on Notch signaling to form the subendothelial medial SMC layers. Approach and Results: Notch elements were expressed in regions of fibrous cap in human and mouse...

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Source

Identifiers

PMID: 34261328
DOI: 10.1161/ATVBAHA.120.315627

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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