Article
Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2006
Adams Lawrence D, Geary Randolph L, Li Jing, Rossini Anthony, Schwartz Stephen M
Abstract excerpt
BACKGROUND: The fibrous cap of the atherosclerotic lesion is believed to be critical to stability because disruption of the cap is the final event leading to plaque rupture. We have, therefore, used expression arrays to define the phenotype of the cap and other plaque components. METHODS AND RESULTS: To identify unique expression programs able to distinguish the smooth muscle of the cap from other plaque smooth...
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