Article

Receptor stoichiometry predicts artery-typical vulnerability to altered Notch signaling during smooth muscle differentiation

2025-05-09

Abstract excerpt

<h4>ABSTRACT</h4> The development and maintenance of arterial smooth muscle cells (SMCs) rely on Jagged1-Notch2/Notch3 signaling. While Notch2 and Notch3 are thought to function redundantly during SMC development, clinical and experimental evidence suggests artery-specific importance for the two receptors. Combining in vitro , in vivo, and in silico models, we report that the canonical Notch signaling during S...

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Literature Corpus work: 36c13ac7-ea25-58d5-b020-ecfabfa03ac7
DOI: 10.1101/2025.05.05.652186

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