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Article

Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice.

The American journal of pathology - 1 Jul 2015

Lin Mu-En, Chen Theodore, Leaf Elizabeth M, Speer Mei Y, Giachelli Cecilia M

Abstract excerpt

Arterial medial calcification (AMC) is a hallmark of aging, diabetes, and chronic kidney disease. Smooth muscle cell (SMC) transition to an osteogenic phenotype is a common feature of AMC, and is preceded by expression of runt-related transcription factor 2 (Runx2), a master regulator of bone development. Whether SMC-specific Runx2 expression is required for osteogenic phenotype change and AMC remains unknown. We...

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Share to Bone Development
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Share to Core Binding Factor Alpha 1 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25987250
DOI: 10.1016/j.ajpath.2015.03.020
PMCID: PMC4484217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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