Article
Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis.
Oxidative medicine and cellular longevity - 1 Jan 2021
Spiecker Lisa, Witte Ines, Mehlig Julia, Shah Viral, Meyerhöfer Markus, Haehnel Patricia S, Petermann Victoria, Schüler Andrea, More Piyush, Cabezas-Wallscheid Nina, Horke Sven, Pautz Andrea, Daiber Andreas, Sasca Daniel, Kindler Thomas, Kleinert Hartmut
Abstract excerpt
BACKGROUND: Long-term hematopoietic stem cells (LT-HSCs) reside in bone marrow niches with tightly controlled reactive oxygen species (ROS) levels. ROS increase results into LT-HSC differentiation and stem cell exhaustion. Paraoxonase 2 (PON2) has been shown to be important for ROS control. OBJECTIVES: We investigate the effects of inactivation of the PON2 gene on hematopoietic cell differentiation and activity....
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