Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gata2 haploinsufficiency promotes proliferation and functional decline of hematopoietic stem cells with myeloid bias during aging

8 Sept 2021

Abstract excerpt

During aging, hematopoietic stem cell (HSC) function wanes with important biological and clinical implications for benign and malignant hematology, and other comorbidities, such as cardiovascular disease. However, the molecular mechanisms regulating HSC aging remain incompletely defined. GATA2 haploinsufficiency driven clinical syndromes initially result in primary immunodeficiencies and routinely evolve into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Immunodeficiency and Autoimmune Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34496012
DOI: 10.1182/bloodadvances.2021004726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gata2 haploinsufficiency promotes proliferation and functional decline of hematopoietic stem cells with myeloid bias during agingPMID 34496012Read ↗

Hematological phenotypes in GATA2 deficiency syndrome arise from aging, maladaptation to proliferation, and somatic eventsSemantic proximity Read ↗

Loss of HSC stemness identity is associated with exhaustion and hyporesponsiveness in GATA2 deficiency syndromeSemantic proximity Read ↗

Impaired DNA damage response and inflammatory signalling underpins hematopoietic stem cell defects in <i>Gata2</i> haploinsufficiencySemantic proximity Read ↗

Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis.Semantic proximity Read ↗

CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness.Semantic proximity Read ↗

Hematological phenotypes in GATA2 deficiency syndrome arise from secondary injuries and maladaptation to proliferationSemantic proximity Read ↗

Aging drives Tet2+/- clonal hematopoiesis via IL-1 signaling.Semantic proximity Read ↗

Mechanisms and rejuvenation strategies for aged hematopoietic stem cellsSemantic proximity Read ↗

Cell intrinsic alterations underlie hematopoietic stem cell agingSemantic proximity Read ↗

Advances in understanding the molecular basis of clonal hematopoiesis.Semantic proximity Read ↗

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells.Semantic proximity Read ↗

Sex-dependent differences in hematopoietic stem cell aging and leukemogenic potentialSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.