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Article

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model.

Blood - 1 Feb 2018

Zhu Xingguo, Xi Caixia, Thomas Bobby, Pace Betty S

Abstract excerpt

The basic leucine zipper transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) plays a critical role in the cellular antioxidant response under oxidative stress conditions. In this study, we investigated the role of NRF2 in fetal hemoglobin expression and the pathophysiology of sickle cell disease (SCD) in a NRF2 knockout (SCD/NRF2-/-) transgenic mouse model. NRF2 loss impaired survival of SCD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29255069
DOI: 10.1182/blood-2017-10-810531
PMCID: PMC5794503

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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