Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanisms of hematopoietic stem cell aging.

Experimental gerontology - 1 Apr 2010

Ergen Aysegul V, Goodell Margaret A

Abstract excerpt

New blood cells are continually produced from the hematopoietic stem cells (HSCs) that reside in the bone marrow. Throughout the life-span of the organism, this stem cell reservoir sustains life. Although HSCs can persist in vivo longer than one life-span (Harrison et al., 1978), with aging, HSC regenerative potential diminishes and skewing from lymphopoiesis toward myelopoiesis occurs. The expansion in the HSC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Gene Expression Regulation
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune System

Share to Phenotype

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 20034552
DOI: 10.1016/j.exger.2009.12.010
PMCID: PMC3632712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of hematopoietic stem cell aging.PMID 20034552Read ↗

Causes and Mechanisms of Hematopoietic Stem Cell AgingSemantic proximity Read ↗

The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging.Semantic proximity Read ↗

Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches.Semantic proximity Read ↗

Mechanisms and rejuvenation strategies for aged hematopoietic stem cellsSemantic proximity Read ↗

Cellular and Molecular Mechanisms Involved in Hematopoietic Stem Cell Aging as a Clinical ProspectSemantic proximity Read ↗

Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging?Semantic proximity Read ↗

Concise review: hematopoietic stem cell aging, life span, and transplantation.Semantic proximity Read ↗

Concise Review: Hematopoietic Stem Cell Aging and the Prospects for RejuvenationSemantic proximity Read ↗

Aging of hematopoietic stem cells is regulated by the stem cell nicheSemantic proximity Read ↗

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche.Semantic proximity Read ↗

Understanding intrinsic hematopoietic stem cell agingSemantic proximity Read ↗

Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.