Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oxidative Stress, Bone Marrow Failure, and Genome Instability in Hematopoietic Stem Cells

22 Jan 2015

Abstract excerpt

Reactive oxygen species (ROS) can be generated by defective endogenous reduction of oxygen by cellular enzymes or in the mitochondrial respiratory pathway, as well as by exogenous exposure to UV or environmental damaging agents. Regulation of intracellular ROS levels is critical since increases above normal concentrations lead to oxidative stress and DNA damage. A growing body of evidence indicates that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to DNA Repair Mechanisms
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25622253
DOI: 10.3390/ijms16022366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oxidative Stress, Bone Marrow Failure, and Genome Instability in Hematopoietic Stem CellsPMID 25622253Read ↗

Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem CellsSemantic proximity Read ↗

Mitochondrial DNA aberrations and pathophysiological implications in hematopoietic diseases, chronic inflammatory diseases, and cancers.Semantic proximity Read ↗

Mitochondrial Contributions to Hematopoietic Stem Cell AgingSemantic proximity Read ↗

Oxidative Stress and Mitochondrial Dysfunction in Myelodysplastic Syndrome: Roles in Development, Diagnosis, Prognosis, and TreatmentSemantic proximity Read ↗

Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cellsSemantic proximity Read ↗

Role of Oxidative Stress in Stem, Cancer, and Cancer Stem CellsSemantic proximity Read ↗

Cellular and Molecular Mechanisms Involved in Hematopoietic Stem Cell Aging as a Clinical ProspectSemantic proximity Read ↗

Oxidative Stress in Fanconi Anemia Hematopoiesis and Disease ProgressionSemantic proximity Read ↗

Understanding intrinsic hematopoietic stem cell agingSemantic proximity Read ↗

The role of DNA damage repair in aging of adult stem cellsSemantic proximity Read ↗

Metabolic Analysis of Mouse Hematopoietic Stem and Progenitor Cells.Semantic proximity Read ↗

Epigenetic Alterations under Oxidative Stress in Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.