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Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells

16 Jul 2008

Abstract excerpt

Hematopoietic stem cells (HSCs) are defined by their ability both to self-renew and to give rise to fresh blood cells throughout the lifetime of an animal. The failure of HSCs to self-renew during aging is believed to depend on several intrinsic (cell-autonomous) and extrinsic (non-cell-autonomous) factors. In this review, we focus on how dysregulation of reactive oxygen species (ROS) and disruptions of genomic...

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PMID: 18627347
DOI: 10.1089/ars.2008.2114

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