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Article

Aging-associated oxidative stress inhibits liver progenitor cell activation in mice.

Aging - 29 Apr 2017

Cheng Yiji, Wang Xue, Wang Bei, Zhou Hong, Dang Shipeng, Shi Yufang, Hao Li, Luo Qingquan, Jin Min, Zhou Qianjun, Zhang Yanyun

Abstract excerpt

Recent studies have discovered aging-associated changes of adult stem cells in various tissues and organs, which potentially contribute to the organismal aging. However, aging-associated changes of liver progenitor cells (LPCs) remain elusive. Employing young (2-month-old) and old (24-month-old) mice, we found diverse novel alterations in LPC activation during aging. LPCs in young mice could be activated and...

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Identifiers

PMID: 28458256
DOI: 10.18632/aging.101232
PMCID: PMC5472737

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