Article
Redox regulation by Pitx2 and Pitx3 is critical for fetal myogenesis.
Developmental cell - 27 May 2014
L'honoré Aurore, Commère Pierre-Henri, Ouimette Jean-François, Montarras Didier, Drouin Jacques, Buckingham Margaret
Abstract excerpt
During development, major metabolic changes occur as cells become more specialized within a lineage. In the case of skeletal muscle, differentiation is accompanied by a switch from a glycolytic proliferative progenitor state to an oxidative postmitotic differentiated state. Such changes require extensive mitochondrial biogenesis leading to increased reactive oxygen species (ROS) production that needs to be...
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