Article

Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity

2023-03-12

Abstract excerpt

Steady state erythropoiesis produces new erythrocytes at a constant rate to replace senescent erythrocytes removed in the spleen and liver. Inflammation caused by infection or tissue damage skews bone marrow hematopoiesis, increasing myelopoiesis at the expense of steady state erythropoiesis. To compensate for the loss of production, stress erythropoiesis is induced. Stress erythropoiesis is highly conserved betwe...

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Literature Corpus work: a8688899-e7ec-5f39-b760-dbbfd1aa9c9c
DOI: 10.1101/2023.03.11.532211

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