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Article

A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress.

Nature communications - 23 Jul 2021

Cacialli Pietro, Mahony Christopher B, Petzold Tim, Bordignon Patrizia, Rougemont Anne-Laure, Bertrand Julien Y

Abstract excerpt

Reactive oxygen species (ROS) represent a by-product of metabolism and their excess is toxic for hematopoietic stem and progenitor cells (HSPCs). During embryogenesis, a small number of HSPCs are produced from the hemogenic endothelium, before they colonize a transient organ where they expand, for example the fetal liver in mammals. In this study, we use zebrafish to understand the molecular mechanisms that are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34301940
DOI: 10.1038/s41467-021-24831-0
PMCID: PMC8302694

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