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Article

Uncoupling protein 2 deficiency results in higher neutrophil counts and lower B-cell counts during aging in mice.

Experimental hematology - 1 Nov 2016

Kretzschmar Christin, Roolf Catrin, Timmer Katrin, Sekora Anett, Knübel Gudrun, Murua Escobar Hugo, Jaster Robert, Müller Sarah, Fuellen Georg, Köhling Rüdiger, Junghanss Christian

Abstract excerpt

Progress of age-related hematopoietic diseases such as myelodysplastic syndrome has previously been linked to enhanced levels of reactive oxygen species (ROS). Uncoupling protein 2 (UCP2) was found to reduce mitochondrial ROS production through uncoupling of the respiratory chain. The impact of UCP2 loss and elevated ROS on hematopoiesis during aging has not yet been investigated. In this study, UCP2 knockout...

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Identifiers

PMID: 27544660
DOI: 10.1016/j.exphem.2016.08.003

Genes

UCP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Uncoupling protein 2 deficiency results in higher neutrophil counts and lower B-cell counts during aging in mice.PMID 27544660Read ↗

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