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Article

Age-dependent alterations in key components of the nigrostriatal dopaminergic system and distinct motor phenotypes.

Acta pharmacologica Sinica - 1 Apr 2022

Fan Jiang-Peng, Geng Hui-Zhen, Ji Ya-Wei, Jia Tao, Treweek Jennifer B, Li An-An, Zhou Chun-Yi, Gradinaru Viviana, Xiao Cheng

Abstract excerpt

The nigrostriatal dopaminergic (DA) system, which includes DA neurons in the ventral and dorsal tiers of the substantia nigra pars compacta (vSNc, dSNc) and DA terminals in the dorsal striatum, is critically implicated in motor control. Accumulating studies demonstrate that both the nigrostriatal DA system and motor function are impaired in aged subjects. However, it is unknown whether dSNc and vSNc DA neurons...

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Identifiers

PMID: 34244603
DOI: 10.1038/s41401-021-00713-5
PMCID: PMC8975991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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