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Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson’s disease

2025-04-23

Abstract excerpt

Neuromelanin (NM) is a dark pigment accumulating with age in human substantia nigra pars compacta (SNpc) dopamine (DA) neurons, conferring the dark look that inspired nigral area’s name. Despite NM has long been associated with Parkinson’s disease (PD), as melanized neurons favorably degenerate during disease development, NM functions within SNpc DA neurons are still mostly elusive. Here, by exploiting an NM-produ...

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Literature Corpus work
37069325-15c3-5d1f-b34e-d5d647ccc52c
DOI
10.1101/2025.04.18.649338
Open publication

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Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson’s diseaseDOI 10.1101/2025.04.18.649338
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