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Article

Synaptic dysfunction in Parkinson's disease.

Advances in experimental medicine and biology - 1 Jan 2012

Picconi Barbara, Piccoli Giovanni, Calabresi Paolo

Abstract excerpt

Activity-dependent modifications in synaptic efficacy, such as long-term depression (LTD) and long-term potentiation (LTP), represent key cellular substrates for adaptive motor control and procedural memory. The impairment of these two forms of synaptic plasticity in the nucleus striatum could account for the onset and the progression of motor and cognitive symptoms of Parkinson's disease (PD), characterized by...

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PMID: 22351072
DOI: 10.1007/978-3-7091-0932-8_24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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