Article

Aging hastens locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression

2024-02-04

Abstract excerpt

Parkinson’s disease (PD) rodent models provide insight into the relationship between nigrostriatal dopamine (DA) signaling and locomotor function. Although toxin-based rat models produce frank nigrostriatal neuron loss and eventual motor decline characteristic of PD, the rapid nature of neuronal loss may not adequately translate premotor traits, such as cognitive decline. Unfortunately, rodent genetic PD models, l...

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Literature Corpus work: 90ecb38b-d3a6-5a16-8229-83b34cbf0c77
DOI: 10.1101/2024.02.01.578317

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