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Article

Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease

13 Jan 2011

Abstract excerpt

ABSTRACT Parkinson's disease (PD) involves progressive loss of nigrostriatal dopamine (DA) neurons over an extended period of time. Mitochondrial damage may lead to PD, and neurotoxins affecting mitochondria are widely used to produce degeneration of the nigrostriatal circuitry. Deletion of the mitochondrial transcription factor A gene ( Tfαm ) in C57BL6 mouse DA neurons leads to a slowly progressing parkinsonian...

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PMID: 21233488
DOI: 10.1096/fj.10-173625

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