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(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse.

Neurobiology of disease - 1 Aug 2014

Chou Jun-Shiao, Chen Chu-Yu, Chen Ying-Ling, Weng Yi-Hsin, Yeh Tu-Hsueh, Lu Chin-Song, Chang Ya-Ming, Wang Hung-Li

Abstract excerpt

Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive neuronal death of substantia nigra pars compacta (SNpc) dopaminergic cells. In the present study, we hypothesized that prior to a late-phase death of SNpc dopaminergic neurons, (G2019S) LRRK2 also causes an early-phase neuronal dysfunction of SNpc dopaminergic cells in the (G2019S) LRRK2 mouse. Eight to nine-month-old...

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PMID: 24830390
DOI: 10.1016/j.nbd.2014.04.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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