Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia.

doi:10.3390/ijms22136657

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Article

Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia.

International journal of molecular sciences - 22 Jun 2021

Diabasana Zania, Perotin Jeanne-Marie, Belgacemi Randa, Ancel Julien, Mulette Pauline, Launois Claire, Delepine Gonzague, Dubernard Xavier, Mérol Jean-Claude, Ruaux Christophe, Gosset Philippe, Maskos Uwe, Polette Myriam, Deslée Gaëtan, Dormoy Valérian

Abstract excerpt

The gene cluster region, CHRNA3/CHRNA5/CHRNB4, encoding for nicotinic acetylcholine receptor (nAChR) subunits, contains several genetic variants linked to nicotine addiction and brain disorders. The CHRNA5 single-nucleotide polymorphism (SNP) rs16969968 is strongly associated with nicotine dependence and lung diseases. Using immunostaining studies on tissue sections and air-liquid interface airway epithelial cell...

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Identifiers

PMID: 34206324
DOI: 10.3390/ijms22136657
PMCID: PMC8268843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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