Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.

doi:10.1016/j.tips.2009.10.004

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Article

Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.

Trends in pharmacological sciences - 1 Jan 2010

Bierut Laura Jean

Abstract excerpt

Due to the adverse health consequences related to smoking, it is important to understand factors that contribute to nicotine dependence. The most replicated genetic finding for nicotine dependence points to variants on chromosome 15, which includes the alpha5-alpha3-beta4 nicotinic receptor gene cluster. A compelling functional variant is a polymorphism, rs16969968, which alters an amino acid in the alpha5...

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Identifiers

PMID: 19896728
DOI: 10.1016/j.tips.2009.10.004
PMCID: PMC2993565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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