Article
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.
PLoS genetics - 5 Aug 2010
Saccone Nancy L, Culverhouse Robert C, Schwantes-An Tae-Hwi, Cannon Dale S, Chen Xiangning, Cichon Sven, Giegling Ina, Han Shizhong, Han Younghun, Keskitalo-Vuokko Kaisu, Kong Xiangyang, Landi Maria Teresa, Ma Jennie Z, Short Susan E, Stephens Sarah H, Stevens Victoria L, Sun Lingwei, Wang Yufei, Wenzlaff Angela S, Aggen Steven H, Breslau Naomi, Broderick Peter, Chatterjee Nilanjan, Chen Jingchun, Heath Andrew C, Heliövaara Markku, Hoft Nicole R, Hunter David J, Jensen Majken K, Martin Nicholas G, Montgomery Grant W, Niu Tianhua, Payne Thomas J, Peltonen Leena, Pergadia Michele L, Rice John P, Sherva Richard, Spitz Margaret R, Sun Juzhong, Wang Jen C, Weiss Robert B, Wheeler William, Witt Stephanie H, Yang Bao-Zhu, Caporaso Neil E, Ehringer Marissa A, Eisen Tim, Gapstur Susan M, Gelernter Joel, Houlston Richard, Kaprio Jaakko, Kendler Kenneth S, Kraft Peter, Leppert Mark F, Li Ming D, Madden Pamela A F, Nöthen Markus M, Pillai Sreekumar, Rietschel Marcella, Rujescu Dan, Schwartz Ann, Amos Christopher I, Bierut Laura J
Abstract excerpt
Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes. In particular, association with the nonsynonymous CHRNA5 SNP rs16969968 and correlates has been replicated in several independent studies. Extensive genotyping of...
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