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Article

The CHRNA5–A3–B4 Gene Cluster and Smoking: From Discovery to Therapeutics

18 Nov 2016

Abstract excerpt

Genome-wide association studies (GWASs) have identified associations between the CHRNA5-CHRNA3-CHRNB4 gene cluster and smoking heaviness and nicotine dependence. Studies in rodents have described the anatomical localisation and function of the nicotinic acetylcholine receptors (nAChRs) formed by the subunits encoded by this gene cluster. Further investigations that complemented these studies highlighted the...

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PMID: 27871728
DOI: 10.1016/j.tins.2016.10.005

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