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Article

Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.

Molecular neurobiology - 1 Jan 2016

Wen Li, Jiang Keran, Yuan Wenji, Cui Wenyan, Li Ming D

Abstract excerpt

Cigarette smoking is the major cause of preventable death and morbidity throughout the world. Many compounds are present in tobacco, but nicotine is the primary addictive one. Nicotine exerts its physiological and pharmacological roles in the brain through neuronal nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels consisting of five membrane-spanning subunits that can modulate the...

Read the complete abstract on PubMed

Topics

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Share to Chromosomes, Human, Pair 15
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nerve Tissue Proteins

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 25471942
DOI: 10.1007/s12035-014-8997-x

Genes

CHRNA5
CHRNA3

Variants

rs16969968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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