An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions.

doi:10.1038/s41467-021-26637-6

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Article

An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions.

Nature communications - 4 Nov 2021

Routhier Julie, Pons Stéphanie, Freidja Mohamed Lamine, Dalstein Véronique, Cutrona Jérôme, Jonquet Antoine, Lalun Nathalie, Mérol Jean-Claude, Lathrop Mark, Stitzel Jerry A, Kervoaze Gwenola, Pichavant Muriel, Gosset Philippe, Tournier Jean-Marie, Birembaut Philippe, Dormoy Valérian, Maskos Uwe

Abstract excerpt

Chronic Obstructive Pulmonary Disease is a generally smoking-linked major cause of morbidity and mortality. Genome-wide Association Studies identified a locus including a non-synonymous single nucleotide polymorphism in CHRNA5, rs16969968, encoding the nicotinic acetylcholine receptor α5 subunit, predisposing to both smoking and Chronic Obstructive Pulmonary Disease. Here we report that nasal polyps from...

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Identifiers

PMID: 34737286
DOI: 10.1038/s41467-021-26637-6
PMCID: PMC8568944

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