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Article

Role of CHRNA5-A3 genetic Locus variants and developing drug for chronic obstructive pulmonary disease.

Current medicinal chemistry - 1 Jan 2012

Lococo F, Cesario A, Petracca-Ciavarella L, Granone P, Russo P

Abstract excerpt

Cigarette smoking is one of the major risk factors for COPD and COPD severity. In turn COPD is a major independent risk factor for lung cancer. Genome-wide association (GWA) studies both in lung cancer and COPD highlighted the same variants (SNPs) on chromosome 15q25 marking the gene cluster CHRNA3-CHRNB4-CHRNA5 for these smoking related diseases, showing a stimulating connection between this common genetic...

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Source

Identifiers

PMID: 23061658
DOI: 10.2174/092986712804143312

Genes

CHRNA5
CHRNA3
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Role of CHRNA5-A3 genetic Locus variants and developing drug for chronic obstructive pulmonary disease.PMID 23061658Read ↗

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