Smoking exposure alters splicing of the nicotinic acetylcholine receptor subunit CHRNA5.

doi:10.1186/s40246-026-01004-y

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Article

Smoking exposure alters splicing of the nicotinic acetylcholine receptor subunit CHRNA5.

Human genomics - 16 Jun 2026

Hogshead Maxwell H, Adu-Gyamfi Atuahene, Papenberg Brenen W, Yan Wusheng, Lee Chia-Han, Florez-Vargas Oscar, Prokunina-Olsson Ludmila

Abstract excerpt

BACKGROUND: Cigarette smoking is the major preventable cancer risk factor. The missense variant rs16969968 (G > A, D398N) in exon 5 of CHRNA5 on chromosome 15q25.1 alters activity of the nicotinic acetylcholine receptor (α5-nAChR) and is associated with increased smoking intensity and cancer risk. We hypothesized that smoking exposure might affect alternative splicing of CHRNA5, which is mainly limited to exon 5,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42304190
DOI: 10.1186/s40246-026-01004-y
PMCID: PMC13508438

Genes

CHRNA5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.