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Article

A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2011

Wei Chongjuan, Han Younghun, Spitz Margaret R, Wu Xifeng, Chancoco Haidee, Akiva Pinchas, Rechavi Gideon, Brand Hadar, Wun Issac, Frazier Marsha L, Amos Christopher I

Abstract excerpt

BACKGROUND: Genetic variants located at 15q25, including those in the cholinergic receptor nicotinic cluster (CHRNA5) have been implicated in both lung cancer risk and nicotine dependence in recent genome-wide association studies. Among these variants, a 22-bp insertion/deletion, rs3841324 showed the strongest association with CHRNA5 mRNA expression levels. However the influence of rs3841324 on lung cancer risk...

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Identifiers

PMID: 22028403
DOI: 10.1158/1055-9965.EPI-11-0749
PMCID: PMC3277830

Genes

CHRNA5
CPD
IMPACT

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