Pax7 pioneer factor action requires both paired and homeo DNA binding domains.

Abstract excerpt

The pioneer transcription factor Pax7 contains two DNA binding domains (DBD), a paired and a homeo domain. Previous work on Pax7 and the related Pax3 showed that each DBD binds a cognate DNA sequence, thus defining two targets of binding and possibly modalities of action. Genomic targets of Pax7 pioneer action leading to chromatin opening are enriched for composite DNA target sites containing juxtaposed sites for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Protein Domains
• Share to Binding Sites
• Share to Cells, Cultured