Article
Autoregulation of Pax6 transcriptional activation by two distinct DNA-binding subdomains of the paired domain.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 1997
Yamaguchi Y, Sawada J, Yamada M, Handa H, Azuma N
Abstract excerpt
BACKGROUND: Pax6 is a transcription factor that plays a central role in eye development. Pax6 contains a DNA-binding domain called paired domain, which consists of a highly conserved N-terminal subdomain and a variable C-terminal subdomain. Recent findings have suggested that both subdomains poss...
Topics
- Animals
- Child
- DNA-Binding Proteins
- Eye Proteins
- Genotype
- Homeodomain Proteins
- Humans
- Male
- Mice
- Models, Molecular
- PAX6 Transcription Factor
- Paired Box Transcription Factors
- Phenotype
- Protein Structure, Tertiary
- Repressor Proteins
- Transcription Factors
- Transcriptional Activation