Article
Autoregulation of Pax6 transcriptional activation by two distinct DNA-binding subdomains of the paired domain.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 1997
Yamaguchi Y, Sawada J, Yamada M, Handa H, Azuma N
Abstract excerpt
BACKGROUND: Pax6 is a transcription factor that plays a central role in eye development. Pax6 contains a DNA-binding domain called paired domain, which consists of a highly conserved N-terminal subdomain and a variable C-terminal subdomain. Recent findings have suggested that both subdomains possess distinct DNA-binding activities. RESULTS: To understand the mechanism of DNA-binding and transcriptional activation...
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