Article
Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations.
Cell - 24 Feb 1995
Xu W, Rould M A, Jun S, Desplan C, Pabo C O
Abstract excerpt
The 2.5 A resolution structure of a cocrystal containing the paired domain from the Drosophila paired (prd) protein and a 15 bp site shows structurally independent N-terminal and C-terminal subdomains. Each of these domains contains a helical region resembling the homeodomain and the Hin recombin...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Crystallography
- DNA
- DNA Nucleotidyltransferases
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Homeodomain Proteins
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Peptide Fragments
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Recombinant Proteins