Article
Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing.
Genes & development - 1 Sept 1994
Epstein J A, Glaser T, Cai J, Jepeal L, Walton D S, Maas R L
Abstract excerpt
Vertebrate Pax proteins share a conserved 128-amino-acid DNA-binding motif, the paired domain. The PAX6 gene, which is mutated in the murine Small eye and human aniridia developmental defects, also encodes a second protein with a 14-amino-acid insertion in the paired domain. This protein, which a...
Topics
- Alternative Splicing
- Animals
- Aniridia
- Base Sequence
- Binding Sites
- Conserved Sequence
- DNA
- DNA Primers
- DNA-Binding Proteins
- Eye Proteins
- Female
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Humans
- Male
- Mice
- Models, Biological
- Molecular Sequence Data